Cronexitide Lanocianine

**Semantic type:** Indicator, Reagent, or Diagnostic Aid

**Definition:** A hydrophobic near-infrared (NIR) fluorescent probe composed of a NIR fluorescent dye cypate linked to an unnatural D-cysteine-containing cyclic octapeptide (D-Cys-Gly-Arg--Asp-Ser-Pro-Cys)-Lys-OH, with potential cancer imaging activity. Upon administration of cronexitide lanocianine during tumor resection, the peptide component specifically targets and binds integrin receptors expressed on tumor cells, which are not expressed on normal, healthy cells. Upon receptor-mediated endocytosis and fluorescence imaging using infrared light that is visualized by the surgeon with special Cancer Vision Goggles (CVG), tumor cells can be detected, identified, and removed accordingly. This enhances the accuracy of cancer cell removal during surgery. The D-cysteine on the peptide prevents degradation by endogenous proteases.

**Synonyms:** - CRONEXITIDE LANOCIANINE - Cypate-cyclo (D-Cys-Gly-Arg--Asp-Ser-Pro-Cys)-Lys-OH - Fluorescent Dye LS301 - LS 301 - LS-301 - LS301 - NIR Fluorescent Probe LS301