Topical Naloxone Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** A topical lotion formulation of the dehydrated, hydrochloride salt form of naloxone, an opiate antagonist, with potential anti-pruritic activity. Upon topical application of the naloxone lotion, naloxone binds to and blocks epidermal mu-opiate receptors. This may suppress or diminish pruritus.

**Synonyms:** - E-0316 - Naloxone Hydrochloride Dehydrate Lotio