Anti-hCD70-CAR Retroviral Vector-transduced Autologous PBLs

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding for a T-cell chimeric antigen receptor (CAR) gene specific for the human cluster of differentiation 70 (CD70), with potential immunostimulatory and antineoplastic activities. Autologous PBLs from a patient with CD70-positive cancer are transduced with a retroviral vector that encodes the CAR gene specific for CD70. After expansion in culture and reintroduction into the patient, anti-hCD70-CAR retroviral vector-transduced autologous PBLs bind to the CD70 antigen on tumor cell surfaces; subsequently, CD70-expressing tumor cells are lysed. CD70, the ligand for the costimulatory receptor CD27, is overexpressed on the surfaces of various cancer cell types.

**Synonyms:** - Anti-hCD70 Autologous CAR-transduced T Cells - Anti-hCD70 CAR autologous PBLs - Anti-hCD70-CAR Retroviral Vector-transduced Autologous Peripheral Blood Lymphocytes