8-Hydroxy-2'-deoxyguanosine

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide

**Definition:** A major spontaneous oxidized derivative of 2'-deoxyguanosine and a biomarker of oxidative DNA damage. 8-hydroxy-2'-deoxyguanosine (8-oxo-dG) is formed through the reaction of guanine with reactive oxygen species. Although normally repaired and removed by the base excision repair mechanism, 8-oxo-dG can potentially mispair with deoxyadenine leading to G-to-T transversion mutations, which cause frequent recombinations and single nucleotide polymorphisms (SNPs) in the human genome. The concentration of 8-oxo-dG within a cell is a measurement of oxidative stress and may thus be used to assess the extent of physiological and environmental damage to DNA.

**Synonyms:** - 2-Amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione - 8-HYDROXY-2'-DEOXYGUANOSINE - 8-Hydroxy-2-deoxyguanosine - 8-OHdG - 8-Oxo-2'-Deoxyguanosine - 8-Oxo-7,8-dihydro-2'-deoxyguanosine - 8-Oxo-dG