Activating ERBB2 Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the ERBB2 gene that results in constitutive receptor tyrosine-protein kinase erbB-2-dependent signal transduction and activation of downstream signaling pathways.

**Synonyms:** - Activating ERBB2 Gene Mutation - Activating HER2 Mutation - CD340 Activating Mutation - ERBB2 Activating Mutation - HER-2 Activating Mutation - HER2/Neu Activating Mutation - c-erbB2 Activating Mutation - c-erbB2 Gene Activation