Activating MET Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the MET gene that results in constitutive hepatocyte growth factor receptor-dependent signal transduction and activation of downstream signaling pathways.

**Synonyms:** - Activating HGFR Mutation - Activating Hepatocyte Growth Factor Receptor Mutation - Activating MET Mutation - Activating MET Mutation - Activating MET Proto-Oncogene, Receptor Tyrosine Kinase Gene Mutation - Activating Met Proto-Oncogene (Hepatocyte Growth Factor Receptor) Mutation - Activating c-Met Mutation - MET Activating Mutation