Activating RET Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the RET gene that results in constitutive proto-oncogene tyrosine-protein kinase receptor Ret-dependent signal transduction and activation of downstream signaling pathways.

**Synonyms:** - Activating RET Mutation - Activating RET Mutation - Activating Ret Proto-Oncogene Mutation - RET Activating Mutation