Glucokinase-Associated Diabetes Mellitus

**Semantic type:** Disease or Syndrome

**Definition:** Monogenic diabetes caused by inactivating mutation(s) in the GCK gene, encoding glucokinase. Heterozygous GCK mutations may manifest as mild hyperglycemia, which is not progressive, and usually requires no treatment. Homozygous GCK mutations result in permanent neonatal diabetes.

**Synonyms:** - GCK-Associated Diabetes Mellitus - MODY2 - Maturity-Onset Diabetes of the Young, Type 2