Hepatocyte Nuclear Factor 1-Beta-Associated Monogenic Diabetes

**Semantic type:** Disease or Syndrome

**Definition:** Monogenic diabetes caused by inactivating mutation(s) in the gene HNF1B, encoding hepatocyte nuclear factor 1-beta. In addition to diabetes, this condition may be associated with renal cysts and urogenital anomalies. Homozygous HNF1B mutations result in permanent neonatal diabetes.