Myeloid/Lymphoid Neoplasms with JAK2 Rearrangement

**Semantic type:** Neoplastic Process

**Definition:** Hematologic neoplasms characterized by the presence of t(8;9)(p22;p24.1) that results in PCM1-JAK2 fusion gene expression. It is associated with eosinophilia, bone marrow findings of left-shifted erythroid predominance, lymphoid aggregates, and often myelofibrosis. Rare cases present as T- or B-acute lymphoblastic leukemia.

**Synonyms:** - M/LN-eo with t(8;9)(p22;p24.1)/PCM1/JAK2 - M/LN-eo with t(8;9)(p22;p24.1)/PCM1::JAK2 - Myeloid and Lymphoid Neoplasms with t(8;9)(p22;p24.1);PCM1-JAK2 - Myeloid and Lymphoid Neoplasms with t(8;9)(p22;p24.1);PCM1::JAK2 - Myeloid/Lymphoid Neoplasm with JAK2 Rearrangement - Myeloid/Lymphoid Neoplasm with JAK2-PCM1 Fusion - Myeloid/Lymphoid Neoplasm with PCM1- JAK2 Fusion - Myeloid/Lymphoid Neoplasms with PCM1-JAK2 - Myeloid/Lymphoid Neoplasms with PCM1-JAK2 - Myeloid/Lymphoid Neoplasms with PCM1::JAK2