Methyl 2,5-dihydroxycinnamate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A cell-permeable analog of erbstatin, a compound isolated from Streptomyces that inhibits the autophosphorylation of epidermal growth factor receptor. Erbstatin analogue competitively inhibits epidermal growth factor receptor-associated tyrosine kinase, inhibiting the activation of v-abl tyrosine kinase. In addition, this agent has induced apoptosis in mouse thymocytes and inhibits the G2/M phase of the cell cycle. (NCI)

**Synonyms:** - 2,4-Dihydroxymethylcinnamate - 2,5-Dihydroxycinnamic Acid Methyl Ester - 3-(2,5-Dihydroxyphenyl)-2-propenoic Acid Methyl Ester - ALX-270-098 - BML-EI146 - Methyl 3-(2,5-dihydroxyphenyl)-2-propenoate - Methyl-2,5-dihydroxycinnamate