Carbon C14 EGFR Inhibitor ASP8273

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate composed of ASP8273, an orally available, third-generation, mutant-selective, irreversible epidermal growth factor receptor (EGFR) inhibitor, labeled with the radioisotope carbon C 14, with potential use for evaluating the pharmacokinetic profile of ASP8273 during positron emission tomography (PET). Upon administration of carbon C 14 ASP8273, ASP8273 targets, covalently binds to and inhibits the activity of mutant forms of EGFR, including the T790M mutant form. Labeling of ASP8273 with the radioactive tracer carbon C 14 permits the evaluation of this agent's pharmacokinetic profile, including its absorption, distribution, metabolism, and excretion (ADME) using PET.

**Synonyms:** - 14C ASP8273 - 14C EGFR Inhibitor ASP8273 - [14C] EGFR Inhibitor ASP8273 - [14C]ASP8273