NSMCE2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human NSMCE2 wild-type allele is located in the vicinity of 8q24.13 and is approximately 275 kb in length. This allele, which encodes E3 SUMO-protein ligase NSE2 protein, is involved in the negative regulation of apoptosis, protein sumoylation, and the promotion of DNA repair. Mutation of the gene is associated with Seckel syndrome 10.

**Synonyms:** - C8orf36 - Chromosome 8 Open Reading Frame 36 Gene - FLJ32440 - MMS21 - MMS21, S. cerevisiae, Homolog of Gene - Methyl Methanesulfonate Sensitivity Gene 21 - NSE2 - NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase wt Allele - Non-SMC Element 2 Homolog (MMS21, S. cerevisiae) Gene - Non-SMC Element 2, MMS21 Homolog (S. cerevisiae) Gene - Non-SMC Element 2, S. cerevisiae, Homolog of Gene - ZMIZ7 - Zinc Finger, MIZ-Type Containing 7 Gene