E3 SUMO-Protein Ligase NSE2

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** E3 SUMO-protein ligase NSE2 (247 aa, ~28 kDa) is encoded by the human NSMCE2 gene. This protein plays a role in DNA double-strand break repair by homologous recombination, the prevention of DNA damage-induced apoptosis, and the sumolyation of protein substrates.

**Synonyms:** - E3 SUMO-Protein Transferase NSE2 - EC 2.3.2.- - EC 6.3.2.-, Formerly - MMS21 Homolog - NSMCE2 - Non-SMC Element 2 Homolog - Non-Structural Maintenance Of Chromosomes Element 2 Homolog - SMC5/SMC6 Complex SUMO Ligase NSMCE2 - hMMS21