POLR3B wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human POLR3B wild-type allele is located in the vicinity of 12q23.3 and is approximately 153 kb in length. This allele, which encodes DNA-directed RNA polymerase III subunit RPC2 protein, plays a role in the synthesis of ribosomal and transfer RNAs. Mutation of the gene is associated with hypomyelinating leukodystrophy-8.

**Synonyms:** - C128 - C128, S. cerevisiae, Homolog of Gene - FLJ10388 - HLD8 - INMAP - Polymerase (RNA) III (DNA Directed) Polypeptide B Gene - Polymerase III, RNA, Subunit B Gene - RNA Polymerase III Subunit B wt Allele - RPC2