Enapotamab Vedotin

**Semantic type:** Pharmacologic Substance

**Definition:** An antibody-drug conjugate (ADC), consisting of a human monoclonal antibody directed against AXL receptor tyrosine kinase (AXL; UFO) and conjugated, through a protease-cleavable linker, to the cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of enapotamab vedotin binds to AXL, which is expressed on the surfaces of a variety of cancer cell types. Upon endocytosis and enzymatic cleavage, MMAE is released into the tumor cell cytosol, where it binds to tubulin and inhibits tubulin polymerization; this may result in G2/M phase arrest and apoptosis. AXL, a member of the TAM (TYRO3, AXL and MER) family of receptor tyrosine kinases and overexpressed by many tumor cell types, plays a key role in tumor cell proliferation, survival, invasion and metastasis; its expression is associated with drug resistance and poor prognosis.

**Synonyms:** - Anti-AXL/MMAE ADC - Anti-AXL/MMAE Antibody-Drug Conjugate - ENAPOTAMAB VEDOTIN - HuMax-AXL-ADC - Immunoglobulin G1, Anti-(Human Growth Factor Receptor axl)(Human Humax-axl Gamma1-chain), Disulfide with Human Humax-axl Kappa-chain, Dimer Tetrakis(thioether) with Vedotin