Fluorine F 18 Vidoflufolastat

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate composed of the phosphoramidate agent vidoflufolastat, a human prostate specific membrane antigen (PSMA) inhibitor, and labeled with the radioisotope fluorine F 18, with potential use as a tracer for PSMA-expressing tumors during positron emission tomography (PET). Upon intravenous administration, fluorine F 18 vidoflufolastat targets and irreversibly binds to the extracellular domain of PSMA-expressing tumor cells. Upon rapid internalization, and following PET imaging, PSMA-expressing tumor cells can be detected. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells.

**Synonyms:** - 18F-CTT-1057 - 18F-CTT1057 - CTT 1057 18F - CTT 1057 F18 - Fluorine F 18 CTT1057 - Fluorine-18-CTT 1057 - PSMA-targeted PET Imaging Agent Fluorine F 18 CTT-1057 - VIDOFLUFOLASTAT F-18 - Vidoflufolastat (18F)