PDE4D wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PDE4D wild-type allele is located in the vicinity of 5q12 and is approximately 1553 kb in length. This allele, which encodes cAMP-specific 3',5'-cyclic phosphodiesterase 4D protein, plays a role in the modulation of second messenger signaling. Mutation of the gene is associated with acrodysostosis 2 and increased susceptibility to stroke.

**Synonyms:** - ACRDYS2 - DPDE3 - HSPDE4D - PDE43 - PDE4DN2 - Phosphodiesterase 4D wt Allele - Phosphodiesterase 4D, cAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E3) Gene - Phosphodiesterase 4D, cAMP-Specific (Phosphodiesterase E3 Dunce Homolog, Drosophila) Gene - Phosphodiesterase 4D, cAMP-Specific Gene - Phosphodiesterase E3 Dunce Homolog (Drosophila) Gene - STRK1