Immune Checkpoint Functional Assay

**Semantic type:** Laboratory Procedure

**Definition:** Various bioassays designed to measure levels of key regulatory molecules, such as PD-1 (PDCD1), CTLA-4, GITR (TNFRSF18), 4-1BB (TNFRSF9), OX40 (TNFRSF4), and TIGIT, that mediate immune checkpoint receptor pathways or assays to measure proliferation, expression of cell surface activation markers, and cytokine expression induced by these pathways.

**Synonyms:** - Checkpoint Signaling Assay - Immune Checkpoint Profile