RHBDF2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human RHBDF2 wild-type allele is located in the vicinity of 17q25.3 and is approximately 31 kb in length. This allele, which encodes inactive rhomboid protein 2, is involved in the regulation of the secretion of various ligands of the epidermal growth factor receptor. Mutation of the gene is associated with tylosis with esophageal cancer.

**Synonyms:** - FLJ22341 - IRHOM2 - RHBDL5 - RHBDL6 - Rhomboid 5 Homolog 2 (Drosophila) Gene - Rhomboid 5 Homolog 2 wt Allele - Rhomboid 5, Drosophila, Homolog of, 2 Gene - Rhomboid, Veinlet-Like 6 (Drosophila) Gene - TEC - TOC - TOCG - Tylosis With Esophageal Cancer Gene - iRhom2