Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

**Semantic type:** Neoplastic Process

**Definition:** Stage III includes: (T3, N2, M0); (T4, N2, M0). T3: Tumor larger than 4 cm in greatest dimension or extension to lingual surface of epiglottis. T4: Moderately advanced local disease. Tumor invades the larynx, extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible or beyond. Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of the larynx. N2: Tumor with metastasis in more than four lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)

**Synonyms:** - Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Squamous Cell Carcinoma AJCC v8 - Stage III HPV-Mediated (p16-Positive) Oropharyngeal Throat Cancer