Anti-Glypican 3-scFvGC33-CAR-expressing T Lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from the anti-glypican-3 (GPC3) monoclonal antibody GC33 (scFvGC33), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-scFvGC33-CAR autologous T-lymphocytes specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells.. GPC3 plays an important role in cellular proliferation and differentiation.

**Synonyms:** - Anti-GPC3-scFvGC33-CAR Autologous T Lymphocytes - Autologous GAP T Cells - Autologous GPC3-CAR T Cells - GPC3-CAR Transduced Autologous T Cells - Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells - Glypican 3-specific Chimeric Antigen Receptor-expressing Autologous T Cells