Dose Expansion Cohort

**Semantic type:** Population Group

**Definition:** A group of subjects in a phase I trial, usually accrued after the maximum tolerated dose maximum tolerated dose has been established. These subjects, often with additional eligibility criteria, are used to: confirm that a safe level of drug exposure has been established, obtain preliminary evidence of efficacy, and identify specific patient subgroups that might derive particular benefits from the investigational treatment.

**Synonyms:** - DEC