Dexrazoxane

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic activity of topoisomerase II, which may result in tumor cell growth inhibition.

**Synonyms:** - (+)-(S)-4,4'-(1-Methyl-1,2-ethanediyl)di(2,6-piperazinedione) - 2, 6-Piperazinedione, 4,4'-propylenedi-, (P)- (8CI) - 2,6-Piperazinedione, 4, 4'-(1-methyl-1,2-ethanediyl)bis-, (S)- (9CI) - 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-,(S)-(9CI) - 2,6-Piperazinedione, 4,4'propylenedi-,(P)-(8CI) - ADR 529 - ADR-529 - ADR529 - DEXRAZOXANE - ICRF 187 - ICRF-187 - ICRF-187 - ICRF187 - Razoxane (+)-form - Soluble ICRF (L-isomer) - dexrazoxane