PA700 Regulatory Module

**Semantic type:** Amino Acid, Peptide, or Protein|Cell Component

**Definition:** Ubiquitinated proteins are degraded by a 26S ATP-dependent protease complex, composed of a 20S catalytic proteasome and two 19S PA700 regulatory modules. The multi-subunit PA700 complex binds two sites of the 20S proteasome and is composed of at least six related ATPases and approximately fifteen non-ATPase polypeptides. Each of the ATPases, PSMC1-6, contains an AAA (ATPases associated with diverse cellular activities) domain. A protein complex containing p42 and p50 enhances PA700 activation of the proteasome.

**Synonyms:** - 19S Proteasome Regulatory Particle - 19S Regulatory Particle - PA700 Protein - PA700 Protein Complex