Boron-dipyrromethene-modified Olaparib Fluorescent Imaging Agent

**Semantic type:** Indicator, Reagent, or Diagnostic Aid

**Definition:** A poly (ADP-ribose) polymerase type 1 (PARP1) fluorescence imaging agent based on the PARP1 inhibitor olaparib, in which the cyclopropane group of olaparib is replaced by the green fluorescent dye boron-dipyrromethene (BODIPY) fluorophore (FL), with potential fluorescent imaging activity. Upon administration of the fluorescent PARP1 inhibitor PARPi-FL, the olaparib binding moiety specifically targets and binds to PARP1, which is often overexpressed on cancer cells. Upon fluorescent imaging, the PARP1-expressing cancer cells can be visualized. PARP1, the nuclear enzyme that catalyzes post-translational ADP-ribosylation of nuclear proteins, is activated by single-strand (SS) DNA breaks and overexpressed in certain tumor cells; it plays a key role in DNA repair, tumor cell resistance and survival.

**Synonyms:** - ABY-029 - AZD2281-BODIPY FL - BODIPY-modified Olaparib Fluorescent Imaging Agent - Boron, (4-((3-((4-(3-(5-((3,5-dimethyl-2H-pyrrol-2-ylidene-kappaN)methyl)-1H-pyrrol-2-yl-kappaN)-1-oxopropyl)-1-piperazinyl)carbonyl)-4-fluorophenyl)methyl)-1(2H)-phthalazinonato)difluoro-, (T-4)- - Fluorescent PARP1 Inhibitor PARPi-FL - Fluorescent PARPi Binding Imaging Agent PARPi-FL - OLAPARIB-BODIPY FL - Olaparib-BODIPY FL - PARPi-FL