t(8;21)(q22;q22)

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A cytogenetic abnormality that involves a translocation between 8q22 and 21q22. It is associated with the development of acute myeloid leukemia with RUNX1-RUNX1T1 fusion protein expression.

**Synonyms:** - Eight-Twenty-One - t(8;21)(q21.3;q22) - t(8;21)(q22;q22.1)