Stage III Appendix Carcinoma AJCC v8

**Semantic type:** Neoplastic Process

**Definition:** Stage III includes: IIIA: (T1, N1, M0); (T2, N1, M0); IIIB: (T3, N1, M0); (T4, N1, M0); IIIC: (Any T, N2, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4: Tumor invades the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or mesoappendix, and/or directly invades adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. N2: Four or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)

**Synonyms:** - Stage III Appendiceal Carcinoma AJCC v8 - Stage III Appendix Cancer