Winged Helix

**Semantic type:** Amino Acid Sequence

**Definition:** A helix-turn-helix type DNA binding domain comprised of two loops formed by twisted antiparallel beta-sheets that resemble wings (W1 and W2), three alpha helices (H1, H2 and H3) and three beta-strands (S1, S2 and S3), which are arranged as follows: H1-S1-H2-H3-S2-W1-S3-W2.

**Synonyms:** - Winged Helix DNA-Binding Domain - Winged Helix-Turn-Helix - wHTH