TRAF Domain

**Semantic type:** Amino Acid Sequence

**Definition:** The TRAF domain is the portion of TRAF family adaptor proteins which bind to TNF receptor cytoplasmic domain. It is the C-terminal homology region of 230 amino acids of signal-transducing proteins associated with members of the TNFR superfamily. This domain is involved in a variety of specific protein-protein interactions.

**Synonyms:** - TNF Receptor-Associated Factor Motif - TRAF Motif