Activating RAF Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A mutation in a RAF family gene that encodes a constitutively active serine/threonine-protein kinase and results in aberrant activation of its downstream pathways.

**Synonyms:** - Activating RAF Family Gene Mutation - Activating Rapidly Accelerated Fibrosarcoma Family Gene Mutation - Activating Rapidly Accelerated Fibrosarcoma Family Kinase Gene Mutation - RAF Family Activating Gene Mutation