Tamnorzatinib

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available and selective inhibitor of the receptor tyrosine kinases (RTKs) Axl (UFO) and Mer, with potential antineoplastic activity. Upon administration, tamnorzatinib targets and binds to both Axl and Mer, and prevents their activity. This blocks Axl- and Mer-mediated signal transduction pathways, and inhibits proliferation and migration of Axl- and Mer-overexpressing tumor cells. Axl and Mer, both members of the TAM (Tyro3, Axl and Mer) family of RTKs, are overexpressed by many tumor cell types. They play key roles in tumor cell proliferation, survival, invasion, angiogenesis and metastasis, and their expression is associated with drug resistance and poor prognosis.

**Synonyms:** - Axl/Mer Inhibitor ONO-7475 - Axl/Mer RTK Inhibitor ONO-7475 - ONO 7475 - ONO-7475 - TAMNORZATINIB