Small Heat Shock Protein

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A family of chaperone proteins with subunit molecular masses of 12-43 kDa. The members are characterized by the presence of a highly conserved stretch of 80-100 amino acids in their C-terminal domains called the alpha-crystallin domain (ACD). Class I small heat shock proteins (sHsps) are widely expressed and play a role in cell survival. Class II sHsps are expressed in tissue-specific patterns and may be involved in the differentiation, development and specific functionality for the tissues they are expressed in.

**Synonyms:** - HSPB - Heat Shock Protein Family B - Heat Shock Protein Family B (Small) - Small Heat Shock Protein Family - sHSP Family - sHsp