RNA Recognition Motif

**Semantic type:** Amino Acid Sequence

**Definition:** RNA Binding Domains (RBD) mediate the interaction of RNAs with RNA-binding proteins. RBDs of about 90 amino acids consist of a four-stranded beta sheet adjacent to two alpha helixes. Within RBDs, conserved RNP-1 and RNP-2 motifs on the central beta sheets lie side by side; their side chains contact RNA.

**Synonyms:** - Putative RNA-Binding Region - RBD - RNA Binding Domain - RNP Domain - RNP Motif - RNP-1 Signature - RRM