G-Quartets

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide

**Definition:** G-quadruplexes are multi-stranded structures held together by square planes of four guanines ('G-quartets') interacting by forming Hoogsteen hydrogen bonds. G-quartet structures has been developed as novel anti-HIV agents. Several critical structure-activity relationships between HIV-1 integrase and G-quartet oligonucleotides have been demonstrated.

**Synonyms:** - G-Quadruplex - G-Quadruplexes - G-Quadruplexes DNA - G-Quartet Structures - G-Tetrads - G4-DNA