Tbo-filgrastim

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A recombinant form of the endogenous cytokine human granulocyte colony-stimulating factor (G-CSF), with hematopoietic activity. Upon administration, tbo-filgrastim specifically binds to and activates G-CSF receptors, thereby controlling the production, differentiation, and function of neutrophilic granulocyte progenitors. This stimulates the proliferation of neutrophils and may decrease the duration and prevent the incidence of chemotherapy-induced neutropenia (CIN). The pharmacokinetic and pharmacodynamic profile of tbo-filgrastim is bioequivalent to filgrastim.