Androgen Receptor Antagonist TAS3681

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable inhibitor of the androgen receptor (AR), with potential antineoplastic activity. Upon oral administration, AR inhibitor TAS3681 specifically binds to AR. This prevents AR activation, downregulates AR and prevents AR-mediated signaling. This inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed in prostate cancers and is involved in proliferation, survival and chemoresistance of tumor cells.

**Synonyms:** - AR Antagonist TAS3681 - Androgen Receptor Inhibitor TAS3681 - TAS 3681 - TAS3681