Edodekin alfa

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with potential antineoplastic activity. Edodekin alfa binds to and activates its cell-surface receptor, stimulating the production of interferon-gamma (IFN) which, in turn, induces IFN-gamma-inducible protein-10 (IP-10) and so inhibits tumor angiogenesis. (NCI04)

**Synonyms:** - Cytotoxic Lymphocyte Maturation Factor - EDODEKIN ALFA - IL-12 - IL-12 - Interleukin 12 - Interleukin-12 - NM-IL-12 - Natural Killer Cell Stimulatory Factor - Recombinant human interleukin-12 (IL-12) cytokine - Ro 24-7472 - interleukin-12