RFWD3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human RFWD3 wild-type allele is located in the vicinity of 16q23.1 and is approximately 45 kb in length. This allele, which encodes E3 ubiquitin-protein ligase RFWD3 protein, plays a role in the modulation of the DNA damage checkpoint of the cell cycle. Biallelic mutations in the gene are associated with Fanconi anemia.

**Synonyms:** - FANCW - FLJ10520 - RNF201 - Ring Finger and WD Repeat Domain 3 wt Allele