Nottingham Grade

**Semantic type:** Classification

**Definition:** A histologic grading system developed by Elston and Ellis as a modification of the Scarff-Bloom-Richardson grading system, based on tubule formation, nuclear pleomorphism, and mitotic counts of invasive adenocarcinomas. (CW Ellston, O Ellis. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology. 1991 Nov;19(5):403-10.)

**Synonyms:** - Elston-Ellis Modification of Scarff-Bloom-Richardson Grading System - Elston-Ellis modification of Scarff-Bloom-Richardson Grading System - NOTTINGHAM HISTOLOGIC GRADE - Nottingham Histologic Grade