Recombinant Macrophage Inflammatory Protein-1 Alpha

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A recombinant therapeutic agent which is chemically identical to or similar to endogenous macrophage inflammatory protein-1, a member of the CC chemokine family produced by activated macrophages. Macrophage inflammatory protein-1 alpha activates granulocytes and induces pro-inflammatory cytokine synthesis. The addition of macrophage inflammatory protein-1 alpha to a vaccine consisting of a DNA immunogen or a pro-inflammatory peptide may enhance vaccine-induced host immune anti-tumor responses. (NCI04)

**Synonyms:** - CCL3 - LD78 - LD78 alpha (e) - MIP-1 Alpha - MIP-1a