Desmosome

**Semantic type:** Cell Component

**Definition:** Desmosomes are intercellular anchoring junctions that anchor intermediate filaments at membrane-associated plaques in adjoining cells. Desmosomes assemble in response to cell-cell contact and raised levels of extracellular calcium. Sensitivity to calcium levels is lost as desmosomes mature.

**Synonyms:** - Desmosomes - Macula Adherens - Spot Desmosome