Trefoil Motif

**Semantic type:** Amino Acid Sequence

**Definition:** Domain found in various secretory polypeptides that has highly conserved cysteine residues that are disulfide bonded in such a way as to generate a trefoil structure (bonded 1-5, 2-4, 3-6). There are also highly conserved A, G and W residues. (The Dictionary of Cell and Molecular Biology - Online)

**Synonyms:** - P Domain - P-Type Domain - TFF Domain - Trefoil - Trefoil Domain