CIC/DUX4 Fusion Protein

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A fusion protein encoded by the CIC/DUX4 fusion gene. This protein is comprised of the majority of the protein capicua homolog, including the DNA-binding high-mobility group (HMG)-box and 15 of 16 putative MAPK phosphorylation sites, fused to the C-terminus of double homeobox protein 4, which results in the loss of both of its DNA-binding homeodomains.

**Synonyms:** - CIC-DUX4 Fusion Protein - CIC::DUX4 Fusion Protein - Protein Capicua Homolog/Double Homeobox 4 Fusion Protein - Protein Capicua Homolog::Double Homeobox 4 Fusion Protein