Activating PTPN11 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the PTPN11 gene that results in constitutive activation of both tyrosine-protein phosphatase non-receptor type 11 and its downstream signaling pathways.

**Synonyms:** - Activating PTPN11 Mutation - Activating PTPN11 Mutation - BPTP3 Activating Mutation - PTP-1D Activating Mutation - PTP2C Activating Mutation - PTPN11 Activating Gene Mutation - PTPN11 Activating Mutation - Protein Tyrosine Phosphatase, Non-Receptor Type 11 Activating Mutation - SH-PTP2 Activating Mutation - SHP-2 Activating Mutation - SHP2 Activating Mutation