Activating BRAF Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the BRAF gene that results in constitutive activation of both serine/threonine-protein kinase B-raf and its downstream signaling pathways.

**Synonyms:** - Activating BRAF Gene Mutation - Activating BRAF1 Mutation - B-RAF Activating Mutation - B-RAF1 Activating Mutation - B-Raf Proto-Oncogene, Serine/Threonine Kinase Activating Mutation - BRAF Activating Mutation - v-raf Murine Sarcoma Viral Oncogene Homolog B Activating Mutation - v-raf Murine Sarcoma Viral Oncogene Homolog B1 Activating Mutation