Activating NRAS Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the NRAS gene that results in constitutive activation of both oncogene N-Ras protein and its downstream signaling pathways.

**Synonyms:** - N-RAS Activating Mutation - NRAS Activating Mutation - NRAS Proto-Oncogene, GTPase Activating Mutation - NRAS1 Activating Mutation - Neuroblastoma RAS Viral Oncogene Homolog Activating Mutation