Activating HRAS Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the HRAS gene that results in constitutive activation of both oncogene H-Ras protein and its downstream signaling pathways.

**Synonyms:** - C-H-RAS Activating Mutation - C-HA-RAS1 Activating Mutation - H-ras Activating Mutation - HRAS Activating Mutation - HRAS1 Activating Mutation - HRas Proto-Oncogene, GTPase Activating Mutation - Ha-ras Activating Mutation - Harvey Rat Sarcoma Viral Oncogene Homolog Activating Mutation - RASH1 Activating Mutation