ITAM

**Semantic type:** Amino Acid Sequence

**Definition:** ITAM (Immunoreceptor Tyrosine-based Activation Motif) or ARAM (Ag Recognition Activation Motif) (Y-X-X-L-(X)6-8-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain, e.g. in CD247/x chain, FceRI g chain, or DAP12. Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases. Motif may be dually phosphorylated on tyrosine that links antigen receptors to downstream signaling machinery.

**Synonyms:** - ARAM - Ag Recognition Activation Motif - Antigen Recognition Activation Motif - Immunoreceptor Tyr-Based Activation Motif - Immunoreceptor Tyrosine-Based Activation Motif - TAM - Tyrosine-Based Activation Motif