ITIM

**Semantic type:** Amino Acid Sequence

**Definition:** ITIM (immunoreceptor Tyr-based inhibition motif) (I/V-X-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain in SHP1 and SHP2, e.g., in KIR family.

**Synonyms:** - Immunoreceptor Tyrosine-Based Inhibitor Motif - Immunoreceptor Tyrosine-Based Inhibitory Motif